For the previous couple of years, more than a few readers have inquired about Mane Biotech (now niostem) and its hair loss App and software. The corporate CEO Dr. Carlos Chacón shared a number of updates with me in 2021, however instructed me that they had been nonetheless in stealth mode. That is now not true, and he e-mailed me some fascinating new main points a few days in the past.
Replace: Might 1, 2023
Niostem Indiegogo Marketing campaign
Niostem despatched me an replace. They now have a set date for his or her legitimate Indiegogo marketing campaign release: Might second, 2023 at 3:00pm Berlin time. Practice their Instagram web page for updates.
- Survive IGG on Might second (hyperlink can be added day after today). Make sure that to enroll in Indiegogo (IGG) first.
- They are going to offer a money-back ensure if the software does now not produce effects (main points can be elaborated on IGG).
- Backers of the marketing campaign (patrons) can have the likelihood to use for the risk to take part in a bigger German medical find out about. Assuming they satisfy the inclusion standards and purchase the software in IGG.
- The collection of units on the market can be restricted.
- The Niostem group was once selected among the “The Top12 Wearable Techpreneurs 2023” within the Wearable Applied sciences Convention Europe 2023. 600 entities submitted their resolution for attention.
February 6, 2023
Pilot Learn about Effects and Scientific Trial in 2023
Once I wrote this put up, Dr. Chacón despatched me a sooner than and after picture and detailed replace. I summarized the details under.
- They name their hair follicle reawakening procedure “Stem Cell Reactivation Technology“.
- In the initial pilot study, after 3 months of continued device usage, hair loss stopped completely in 95.4% of patients, and most of those also showed some hair regrowth. Moreover, after 6 months of use, 100% of participants saw a cessation in hair loss. And they showed an average hair growth of 19.3% and an average hair thickness increase of 9% .
- There were minimal adverse side effects: itchy scalp (scalp pruritus) in 9% of patients and a slight headache in 4.5% of patients. All during the first 2-4 days of use.
- Niostem plans to initiate a much larger clinical trial in Germany in the middle of 2023. Recruitment starts soon and they will likely include some potential customers.
- The internal pilot was a 6-month clinical validation study consisting of 22 men between 21 and 40 years of age. All had male pattern baldness (Norwood scale 2-6). The quantitative hair density analysis was independently performed in a blind manner by Surry Trichology Clinic, UK through trichoscopy imaging.
- Their results were 6x more effective in hair regrowth and 2x faster than the top FDA-approved anti-hair loss drug, Finasteride. The mean hair density increase with Niostem at 6 months was 42 hairs/cm2. In comparison, it was a 7.2 hairs/cm2 increase after 12 months of Finasteride 1 mg per day use (based on Neste et al, 2000). Not sure why they picked this particular study for comparison.
- With Monasterium Lab, they ran some ex vivo experiments (proof-of-principle/concept) with follicular units. Niostem collaborated with them as a CRO.
Niostem: New Name for Mane Biotech
Of most importance, Mane Biotech has been rebranded to niostem. On the new company’s website, it says that they are headquartered in Germany and the hair loss device will be launched in 2023. Note that niostem’s co-founders are Dr. Chacón and a person named Emil Aliev.
The before and after photos on niostem’s website show significant hair growth after 6 months of device use. One of the reasons that this product is coming out so fast is because no clinical trials seem to have been required. I am pleased about this, because most companies that undergo three phases of clinical trials take forever (e.g., Follica) or often give up due to lack of funding.
Note there there is one online anecdotal report on the German hair loss forum from someone who took part in a Mane Biotech study. Not sure if reliable.
Dr. Chacón previously worked at the prestigious Max Planck Institute for Biology for Ageing in Germany. Some of his past research on hair follicle stem cells can be found here and on his Linkedin.
He is one of the co-applicants in a patent filed by the Max Planck Institute in 2016. It entails the culturing of epidermis-derived stem cells, including hair follicles. Among the papers co-authored by Dr. Carlos Chacón-Martínez include a 2021 one on hair follicle stem cell fate.
Electrical Stimulation of the Scalp
Interestingly, one of his patents relates to an electric device to stimulate hair growth. It was filed in 2020 by Mane Biotech and is still pending. I suspect that niostem’s new low-level electrical stimulation hair growth device makes use of the discoveries in the above patent.
Although this concept might sound like fantasy, I actually wrote an entire post on electricity and hair growth in the past. There is some evidence that electric stimulation can reactivate the dormant stem cells surrounding miniaturized hair follicles. Thereby leading to hair regeneration.
On a related note, hair growth lasers also work via a similar concept, but involve light energy instead of electricity. And recently, I also discussed sound energy and hair growth.
Niostem Device Releasing in 2023
According to the podcast embedded at the bottom of this post, the wearable device is lightweight and wireless. It needs to be used a few days a week for life if you want to hold on to any gains. On niostem’s website FAQ section, it says the product will release in 2023.
Among the advantages of this device versus most existing hair loss treatment options include:
- No side effects that can happen with medications.
- Ease of use. You can wear it like a cap or helmet while doing chores. But do not use it outdoors in case of rain or snow.
- No messy application process such as with topical hair loss products or hair thinning shampoos.
Niostem’s Twitter and Instagram pages can be followed for the latest updates.
Last month, Dr. Chacon gave an interview on the “Products with Purpose” podcast this is value a pay attention. The corporate has been running in this wearable software for nearly 4 years. He mentions that they verified their effects at the well-known 3rd birthday celebration Monasterium Laboratory. The hair enlargement building up after 6 months of software use was once 19%.
They plan to release an Indiegogo crowdfunding spherical in March. This generation has additional implications to total stem cellular rejuvenation and human well being and longevity.
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